Just another post to help the random person searching or an issue.
I was having random hard lockups and Chromium based browsers, (Edge, Chrome, and Brave were tested... although funnily enough Edge Beta never did it). I got to the point where I had no extensions running, incognito mode and it still happened, and if you had multiple chrome profiles open, which run as their own process it would freeze all of them. Needless to say this was quite annoying during the workday. Firefox luckily did not have the issue, where most of my browsing is done anyway.... Once I eliminated it wasn't any profiles or extension issue, I had to turn elsewhere, which I started just close a piece of software on the computer, test, and repeat. Closing Zoom seemed to fix it, but then it didn't. This was odd because it was so consistently freezing my dropdown menus in ServiceNow (the main place I was able to replicate the issue)...
So I take a gander at the event viewer and see the SDZoom plugin crashing every 10 or so minutes. (I'm not the only one https://github.com/smitmartijn/streamdeck-zoom-plugin/issues/26 )
Honestly I just got the streamdeck not too long ago and got plugin happy trying all sorts of things, and all those plugin commands sat about 2 folders deep and never quite worked the way I expected them to, seemed to always try and alt tab, it wasn't like global commands, which could've been really nice. So I removed the plugin, and low and behold no more issues with my chrome drop down menus.
Now the correlation that caused this, has got to be something with UI automation of some sort trying to read the screen data, and my monitor setup might also be a little extreme complicating matters, I'm not sure.